FEATURES

FAMILY

DESCRIPTION

Also known as SOAT2_HUMAN, SOAT2, ACACT2, ACAT2. Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16647063, PubMed:11294643). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:11294643). Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z, 12Z, 15Z)-octadecatrienoyl-CoA) as substrates (PubMed:11294643). May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa (PubMed:11294643)., Has lower enzymatic activity compared to isoform 1., Has lower enzymatic activity compared to isoform 1. May form homo- or heterodimers (By similarity). Interacts with INSIG1; the interaction is direct and promotes association with AMFR/gp78 (PubMed:28604676).

Also known as SOAT2_HUMAN, SOAT2, ACACT2, ACAT2. Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16647063, PubMed:11294643). ...

EXTERNAL LINKS

SOAT2

Sterol O-acyltransferase 2

Mutations

Mutation(s) distribution

Mutations table

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