FEATURES

FAMILY

cyclic nucleotide phosphodiesterase family

DESCRIPTION

Also known as PDE5A_HUMAN, PDE5A, PDE5. Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PDE5A

cGMP-specific 3', 5'-cyclic phosphodiesterase

Mutations

Mutation(s) distribution

Mutations table

Search Mutation