FEATURES

FAMILY

DESCRIPTION

Also known as SMC1_SCHPO, psm1, smc1. Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesin complexes are composed of the psm1/smc1 and psm3/smc3 heterodimer attached via their SMC hinge domain, rad21/scc1 which link them, and psc3/scc3, which interacts with rad21.

EXTERNAL LINKS

psm1

Mutations

Mutation(s) distribution

Mutations table