FEATURES

FAMILY

DESCRIPTION

Also known as STK10_HUMAN, STK10, LOK. Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo. Homodimer; homodimerization is required for activation segment autophosphorylation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

STK10

Mutations

Mutation(s) distribution

Mutations table