FEATURES

FAMILY

DESCRIPTION

Also known as MICA2_HUMAN, MICAL2, KIAA0750, MICAL2PV1, MICAL2PV2. Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334). In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334). Interacts with PLXNA4 (By similarity). Interacts with RAB1B (PubMed:15694364).

EXTERNAL LINKS

MICAL2

[F-actin]-monooxygenase MICAL2

MICAL2

Molecular Synopsis