FEATURES

DESCRIPTION

Also known as MBD4_HUMAN, MBD4, MED1. Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. Interacts with MLH1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MBD4

Methyl-CpG-binding domain protein 4

MBD4

Molecular Synopsis