FEATURES

FAMILY

DESCRIPTION

Also known as GA45G_HUMAN, GADD45G, CR6, DDIT2. Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Undergoes concentration-dependent homodimerization, which is required for growth inhibititory activity and enhances interaction with PCNA. Interacts with GADD45GIP1. Interacts with PCNA.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GADD45G

Growth arrest and DNA damage-inducible protein GADD45 gamma

GADD45G

Molecular Synopsis