FEATURES

FAMILY

DESCRIPTION

Also known as MPZL1_HUMAN, MPZL1, PZR. Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 3 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2 and isoform 3, may be involved in regulation of integrin-mediated cell motility. Interacts with phosphorylated PTPN11/SHP-2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MPZL1

Mutations

Mutation(s) distribution

Mutations table