FEATURES

DESCRIPTION

Also known as CNOT4_HUMAN, CNOT4, NOT4. Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved in activation of the JAK/STAT pathway (PubMed:11823428, PubMed:22159038). Catalyzes ubiquitination of methylated RBM15 (PubMed:26575292). Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA (PubMed:29861391). As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy (PubMed:29861391). Interacts with CNOT1 via its C-terminus but does not stably associate with the CCR4-NOT complex (PubMed:11823428). Interacts (via RING domain) with UBE2D2 (PubMed:15001359). Interacts with ABCE1, PINK1 and PELO (PubMed:29861391).

Also known as CNOT4_HUMAN, CNOT4, NOT4. Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins (PubMed:11823428, PubMed:22159038, PubMed:26575292). Involved ...

EXTERNAL LINKS

CNOT4

CCR4-NOT transcription complex subunit 4

CNOT4

Molecular Synopsis