FEATURES

FAMILY

DESCRIPTION

Also known as M4K4_HUMAN, MAP4K4, HGK, KIAA0687, NIK. Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. Interacts with the SH3 domain of the adapter proteins Nck (By similarity). Interacts (via its CNH regulatory domain) with ATL1 (via the N-terminal region). Interacts with RAP2A (GTP-bound form preferentially).

Also known as M4K4_HUMAN, MAP4K4, HGK, KIAA0687, NIK. Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MAP4K4

Mitogen-activated protein kinase kinase kinase kinase 4

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

MAP4K4

Structural Ligandability

Domains Chains

Distribution