FEATURES

FAMILY

DESCRIPTION

Also known as TOM40_HUMAN, TOMM40, C19orf1, PEREC1, TOM40. Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria (PubMed:31206022). Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with mitochondrial targeting sequences (PubMed:12198123, PubMed:15644312, PubMed:18331822). Interacts with TIMM29; linking the TIM22 complex to the TOM complex (PubMed:27554484). Forms a complex with BCAP31 (via C-terminus) which mediates the translocation of components of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) from the cytosol to the mitochondria (PubMed:31206022). Interacts (via N-terminus) with CYP1A1 (via mitochondrial targeting signal); this interaction is required for CYP1A1 translocation across the mitochondrial outer membrane (By similarity).

Also known as TOM40_HUMAN, TOMM40, C19orf1, PEREC1, TOM40. Channel-forming protein essential for import of protein precursors into mitochondria (PubMed:15644312, PubMed:31206022). Plays a role in ...

EXTERNAL LINKS

TOMM40

Mitochondrial import receptor subunit TOM40 homolog

TOMM40

Molecular Synopsis