FEATURES

FAMILY

zinc-containing alcohol dehydrogenase family

DESCRIPTION

Also known as ADH1B_HUMAN, ADH1B, ADH2. Catalyzes the NAD-dependent oxidation of all-trans-retinol and its derivatives such as all-trans-4-hydroxyretinol and may participate in retinoid metabolism (PubMed:15369820, PubMed:16787387). In vitro can also catalyzes the NADH-dependent reduction of all-trans-retinal and its derivatives such as all-trans-4-oxoretinal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:16787387). Has the same affinity for all-trans-4-hydroxyretinol and all-trans-4-oxoretinal (PubMed:15369820). Dimer of identical or non-identical chains of three types; alpha, beta and gamma.

EXTERNAL LINKS

ADH1B

Mutations

Mutation(s) distribution

Mutations table