FEATURES

FAMILY

glyceraldehyde-3-phosphate dehydrogenase family

DESCRIPTION

Also known as G3P_THEAQ, gap. Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1, 3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification

gap

Mutations

Mutation(s) distribution

Mutations table