FEATURES

FAMILY

DESCRIPTION

Also known as FRDA_ECOLI, frdA. Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; fumarate reductase is used during anaerobic growth, and succinate dehydrogenase is used during aerobic growth. The QFR enzyme complex binds 2 quinones in or near the membrane; 1 near the [3Fe-4S] cluster (QP is proximal to the [3Fe-4S] cluster, on the cytoplasmic side of the membrane) while QD (the distal cluster) is on the other side of the membrane. It is not clear if both of the quinol-binding sites are functionally relevant (PubMed:10373108, PubMed:11850430). Part of an enzyme complex containing four subunits: a flavoprotein (FrdA), an iron-sulfur protein (FrdB), and two hydrophobic anchor proteins (FrdC and FrdD) (PubMed:10373108, PubMed:11850430). Can be cross-linked to SdhE (PubMed:26644464). Purified from membrane fractions associated with protoporphyrinogen IX dehydrogenase (hemG) (PubMed:20484676).

EXTERNAL LINKS

frdA

Fumarate reductase flavoprotein subunit

frdA

Molecular Synopsis