FEATURES

FAMILY

ribonucleoside diphosphate reductase large chain family

DESCRIPTION

Also known as RIR1_ECOLI, nrdA, dnaF. Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. R1 contains the binding sites for both substrates and allosteric effectors and carries out the actual reduction of the ribonucleotide. It also provides redox-active cysteines. Tetramer of two alpha (R1) and two beta (R2) subunits. The B1 protein is a dimer of alpha subunits. A radical transfer pathway occurs between 'Tyr-122' of R2 and R1.

EXTERNAL LINKS

uniprot
enzyme classification

nrdA

Ribonucleoside-diphosphate reductase 1 subunit alpha

Mutations

Mutation(s) distribution

Mutations table

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