FEATURES

FAMILY

DESCRIPTION

Also known as PA2B_NOTSC, PA2B. Snake venom phospholipase A2 (PLA2) that inhibits neuromuscular transmission by blocking acetylcholine release from the nerve termini. Is directly toxic to skeletal muscle upon local application in vivo (dystrophic effect). Also has direct nephrotoxicity in experimental mice; a single subcutaneous dose (1.38 ug/kg) produces renal tubular and glomerular damage within 24 hours (PubMed:7580101). PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

PA2B

Basic phospholipase A2 notexin

PA2B

Molecular Synopsis