FEATURES

FAMILY

DESCRIPTION

Also known as FA12_HUMAN, F12. Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa. Interacts with HRG; the interaction, which is enhanced in the presence of zinc ions and inhibited by heparin-binding, inhibits factor XII autoactivation and contact-initiated coagulation.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

F12

Coagulation factor XII

F12

Molecular Synopsis