FEATURES

FAMILY

DESCRIPTION

Also known as ASSY_HUMAN, ASS1, ASS. One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. Homotetramer (PubMed:18323623). Interacts with NMRAL1 (PubMed:17496144). Interacts with CLOCK; in a circadian manner (PubMed:28985504).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ASS1

Mutations

Mutation(s) distribution

Mutations table