FEATURES

FAMILY

DESCRIPTION

Also known as ANT3_HUMAN, SERPINC1, AT3. Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin. Forms protease inhibiting heterodimer with TMPRSS7.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SERPINC1

Antithrombin-III

SERPINC1

Molecular Synopsis