FEATURES

DESCRIPTION

Also known as BNP_GLOBL, BNP. inhibits the rabbit lung angiotensin-converting enzyme (ACE) (IC(50)=15 uM) (PubMed:10866809). Contracts the rat gastric fundus smooth muscle in a rapid and transient manner (PubMed:10519653, PubMed:10866809)., causes no contraction of the rat gastric fundus smooth muscle even at high concentrations. Causes very weak contraction of the isolated guinea pig ileum (PubMed:4323853). Causes weak contraction on rat uterus (PubMed:4323853)., inhibits the activity of the angiotensin-converting enzyme (ACE) by a preferential interaction with its C-domain (Ki=30 nM, IC(50)=1.1 uM) (PubMed:10866809, PubMed:11994001, PubMed:23082758). It binds ACE in a zinc-independent manner (PubMed:23056909). Also potentiates the hypotensive effects of bradykinin. Causes high contraction of the isolated guinea pig ileum and weak contraction on rat uterus (PubMed:4323853)., inhibits the activity of the angiotensin-converting enzyme (ACE) by interacting with the same potency to its C- and N-domains (PubMed:11994001). Inhibits the rabbit lung angiotensin-converting enzyme (ACE) (IC(50)=7.1 uM) (PubMed:10866809). Causes weak contraction of the isolated guinea pig ileum (PubMed:4323853). Causes weak contraction on rat uterus (PubMed:4323853)., inhibits the rabbit lung angiotensin-converting enzyme (ACE) (IC(50)=46 uM) (PubMed:10866809). Synthetic Leu3-blomhotin contracts the rat gastric fundus smooth muscle in a rapid and transient manner (PubMed:10866809). Causes moderate contraction of the isolated guinea pig ileum (PubMed:4323853). Causes weak contraction on rat uterus (PubMed:4323853)., causes weak contraction of the isolated guinea pig ileum (PubMed:4323853). Causes about 50-fold more potentiating activity on rat uterus than on guinea pig ileum (PubMed:4323853)., synthetic peptide potentiates the bradykinin in vivo., synthetic peptide does not show any bradykinin-potentiating effects., exhibits hypotensive and vasodepressor activity. Acts by activating natriuretic receptors (NPR1 and/or NPR2 and/or NPR3) (By similarity).

EXTERNAL LINKS

BNP

Bradykinin-potentiating and C-type natriuretic peptides

BNP

Molecular Synopsis