FEATURES

FAMILY

DESCRIPTION

Also known as ATIF1_BOVIN, ATP5IF1, ATPI, ATPIF1. Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Homodimer; represents the active form and is present at a pH value below 6.5. Homotetramer; represents the inactive form and is present at a pH value above 7.0.

EXTERNAL LINKS

uniprot
enzyme classification

ATP5IF1

ATPase inhibitor, mitochondrial

ATP5IF1

Molecular Synopsis