FEATURES

FAMILY

glycoprotein hormones subunit beta family

DESCRIPTION

Also known as FSHB_HUMAN, FSHB. Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (PubMed:2494176, PubMed:24692546). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:407105, PubMed:8220432). Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

FSHB

Mutations

Mutation(s) distribution

Mutations table