FEATURES

FAMILY

staphylococcal/streptococcal toxin family

DESCRIPTION

Also known as ETXB_STAAU, entB. Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines (PubMed:2303780, PubMed:25015819). Causes also the intoxication staphylococcal food poisoning syndrome (By similarity). Interacts with MHC class II molecules composed of alpha/HLA-DRA and beta/HLA-DRB1 chains (PubMed:8152483, PubMed:25015819). Interacts with T-cell receptor beta variable 19/TRBV19 (PubMed:9881971, PubMed:25015819).

EXTERNAL LINKS

entB

Enterotoxin type B

entB

Molecular Synopsis