FEATURES

FAMILY

DESCRIPTION

Also known as NFL_PIG, NEFL. Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). Forms homodimers (in vitro) (By similarity). Forms heterodimers with NEFH or NEFM; which can further hetero-oligomerize (in vitro) (By similarity). Forms heterodimers with INA (in vitro) (By similarity). Interacts with ARHGEF28. Interacts with TRIM2.

EXTERNAL LINKS

uniprot
enzyme classification

NEFL

Neurofilament light polypeptide

NEFL

Structural Ligandability

Domains Chains

Distribution