FEATURES

FAMILY

ligand-gated ion channel (TC 1.A.9) family

DESCRIPTION

Also known as ACHA_HUMAN, CHRNA1, ACHRA, CHNRA. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. The muscle heteropentamer composed of alpha-1, beta-1, delta, epsilon subunits interacts with the alpha-conotoxin ImII (PubMed:15609996).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CHRNA1

Acetylcholine receptor subunit alpha

CHRNA1

Molecular Synopsis