FEATURES

FAMILY

DESCRIPTION

Also known as PLF4_HUMAN, PF4, CXCL4, SCYB4. Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Homotetramer.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PF4

Mutations

Mutation(s) distribution

Mutations table