FEATURES

FAMILY

outer membrane factor (OMF) (TC 1.B.17) family

DESCRIPTION

Also known as TOLC_ECOLI, tolC, colE1-i, mtcB, mukA, refI, toc, weeA. Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, EmrAB-TolC and MacAB-TolC. These systems are involved in export of antibiotics and other toxic compounds from the cell. TolC is also involved in import of colicin E1 into the cells. Homotrimer. Part of tripartite efflux systems, which are composed of an inner membrane transporter, a periplasmic membrane fusion protein, and an outer membrane component, TolC. The complexes form a large protein conduit and can translocate molecules across both the inner and outer membranes. TolC interacts with the membrane fusion proteins AcrA, EmrA and MacA.

Also known as TOLC_ECOLI, tolC, colE1-i, mtcB, mukA, refI, toc, weeA. Outer membrane channel, which is required for the function of several efflux systems such as AcrAB-TolC, AcrEF-TolC, Emr ...

EXTERNAL LINKS

tolC

Structural Ligandability

Domains Chains

Distribution