FEATURES

DESCRIPTION

Also known as TF3A_XENLA, gtf3a. Involved in ribosomal large subunit biogenesis (By similarity). Acts as both a positive transcription factor for 5S RNA genes and a specific RNA binding protein that complexes with 5S RNA in oocytes to form the 7S ribonucleoprotein storage particle. May play an essential role in the developmental change in 5S RNA gene expression. Interacts with the internal control region (ICR) of approximately 50 bases within the 5S RNA genes, is required for correct transcription of these genes by RNA polymerase III (PubMed:2253880, PubMed:1538401, PubMed:1762917). Also binds the transcribed 5S RNA's (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

gtf3a

Mutations

Mutation(s) distribution

Mutations table