FEATURES

FAMILY

adenoviridae hexon-interlacing protein family

DESCRIPTION

Also known as CAP9_ADE05, IX. Structural component of the virion that acts as a cement protein on the capsid exterior and forms triskelion structures consisting of three molecules that stabilize three hexon trimers at the center of each icosahedral facet and fixes the peripentonal hexons. Dispensable for assembly. During virus entry, recruits the anterograde motor kinesin-1 to the capsid docked at the nuclear pore complex thereby subjecting the docked capsid to a pulling force. The resulting tension leads to capsid disruption, dispersion of capsid fragments toward cell periphery and eventually viral DNA entry into the host nucleus. Homotrimer. Interacts with hexon protein; this interaction tethers the hexons together (PubMed:20798312, PubMed:25071205). Self-interacts with adjacent proteins (PubMed:20798312, PubMed:25071205). Interacts with kinesin light chain KLC1; this interaction leads to capsid disruption at the nuclear pore complex during virus entry into host cell (By similarity).

EXTERNAL LINKS

IX

Structural Ligandability

Domains Chains

Distribution