FEATURES

FAMILY

vesiculovirus nucleocapsid protein family

DESCRIPTION

Also known as NCAP_VSIVA, N. Encapsidates the genome in a ratio of one N per nine ribonucleotides, protecting it from nucleases. The encapsidated genomic RNA is termed the NC and serves as template for transcription and replication. Nucleocapsid assembly is concommitant with replication, therefore viral replication depends on the intracellular concentration of free N, termed N(0). All replicative products are resistant to nucleases. Homomultimerizes to form the nucleocapsid. Binds to viral genomic RNA (PubMed:11000221). N in nucleocapsid binds the P protein and thereby positions the polymerase on the template (PubMed:3016338). Interaction of N(0) with the P protein prevents the uncontrolled aggregation of N(0) (PubMed:21207454).

EXTERNAL LINKS

N

Structural Ligandability

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Distribution