FEATURES

FAMILY

DESCRIPTION

Also known as KLKB1_HUMAN, KLKB1, KLK3. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Forms a heterodimer with SERPINA5. The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.

Also known as KLKB1_HUMAN, KLKB1, KLK3. The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

KLKB1

Mutations

Mutation(s) distribution

Mutations table