FEATURES

DESCRIPTION

Also known as VWF_HUMAN, VWF, F8VWF. Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma. Multimeric. Interacts with F8.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

VWF

Mutations

Mutation(s) distribution

Mutations table