FEATURES

FAMILY

DESCRIPTION

Also known as GNAS2_BOVIN, GNAS, GNAS1. Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:2022671, PubMed:9395396, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2 (By similarity). Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (PubMed:9395396, PubMed:9417641, PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). Interacts with CRY1; the interaction may block GPCR-mediated regulation of cAMP concentrations. Interacts with ADCY6 and stimulates its adenylyl cyclase activity (By similarity). Interacts with ADCY2 and ADCY5 (PubMed:9395396, PubMed:9417641, PubMed:10427002, PubMed:11087399, PubMed:15591060, PubMed:16766715, PubMed:19243146). Stimulates the ADCY5 adenylyl cyclase activity (By similarity). Interaction with SASH1 (By similarity). Interacts with GASL2L2 (By similarity).

EXTERNAL LINKS

GNAS

Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Structural Ligandability

Domains Chains

0 chains assessed

1 chain not associated with a domain

GNAS

Structural Ligandability

Domains Chains

Distribution