FEATURES

FAMILY

DESCRIPTION

Also known as IC1_HUMAN, SERPING1, C1IN, C1NH. Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Interacts with MASP1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SERPING1

Plasma protease C1 inhibitor

SERPING1

Molecular Synopsis