FEATURES

FAMILY

DESCRIPTION

Also known as NUPL_XENLA, NUPL. Acts as a chaperone for histones, such as histone H2A-H2B, and thus regulates the assembly of nucleosome cores (PubMed:11684019, PubMed:19055325). Involved in chromatin remodeling, especially during fertilization and early embryonic development (By similarity). May be involved in sperm chromatin decondensation during fertilization (PubMed:17510054). Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously. Interacts with the heterotetramer formed by wdr77 and prmt5.

EXTERNAL LINKS

uniprot
enzyme classification

NUPL

Mutations

Mutation(s) distribution

Mutations table