FEATURES

FAMILY

DESCRIPTION

Also known as ICAM1_HUMAN, ICAM1. ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation., (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins., (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins., (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. Homodimer (Probable). Interacts with MUC1 and promotes cell aggregation in epithelial cells. Interacts with ARHGEF26/SGEF. Interacts (on T cell side) with CD81, CD247 and CD9 at immunological synapses between antigen-presenting cells and T cells.

EXTERNAL LINKS

ICAM1

Intercellular adhesion molecule 1

ICAM1

Molecular Synopsis