FEATURES

FAMILY

DESCRIPTION

Also known as O17A_CONMA, O17A. Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels. This toxin blocks Cav2.2/CACNA1B calcium channels (IC(50)=180 nM). When injected in mammals, it induces adverse effects, such as tremor, diminution of spontaneous locomotor activity and bad coordinated locomotion (PubMed:26344359).

EXTERNAL LINKS

uniprot
enzyme classification

O17A

Omega-conotoxin MVIIA

Mutations

Mutation(s) distribution

Mutations table

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