FEATURES

FAMILY

DESCRIPTION

Also known as HEP2_HUMAN, SERPIND1, HCF2. Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner., Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SERPIND1

Heparin cofactor 2

SERPIND1

Molecular Synopsis