FEATURES

FAMILY

DESCRIPTION

Also known as GELS_HUMAN, GSN. Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Binds to actin and to fibronectin. Identified in a complex composed of ACTA1, COBL, GSN AND TMSB4X. Interacts with the inactive form of EIF2AK2/PKR (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GSN

Mutations

Mutation(s) distribution

Mutations table