FEATURES

FAMILY

DESCRIPTION

Also known as P56_BPPZA, 1B. Inhibits the host uracil-DNA glycosylase (UDG), an enzyme which removes uracil residues from DNA by the base excision repair. Interacts with host uracil-DNA glycosylase and prevents the latter from binding to DNA. Since the viral DNA polymerase efficiently incorporates dUMP into DNA, the virus needs to prevent the deleterious effect caused by host UDG when it eliminates uracil residues present in the viral genome. Homodimer. Interacts with host UDG; this interaction inhibits the uracil-DNA glycosylase ().

EXTERNAL LINKS

uniprot
enzyme classification

1B

Mutations

Mutation(s) distribution

Mutations table