FEATURES

FAMILY

DESCRIPTION

Also known as FHUA_ECOLI, fhuA, tonA. Involved in the uptake of iron in complex with ferrichrome, a hydroxamate-type siderophore. Binds and transports ferrichrome-iron across the outer membrane (PubMed:1089064, PubMed:2066336). In addition to its role in ferrichrome-iron transport, transports the antibiotic albomycin, which is a structural analog of ferrichrome, and acts as a receptor for colicin M, microcin J25 and bacteriophages T1, T5, phi80 and UC-1 (PubMed:1089064, PubMed:353030, PubMed:2066336, PubMed:8617231). The energy source, which is required for all FhuA functions except infection by phage T5, is provided by the inner membrane TonB system (PubMed:353030, PubMed:9353297, PubMed:12427941). Monomer (PubMed:8916906, PubMed:9856937, PubMed:9865695). Interacts with TonB (PubMed:9353297, PubMed:12427941, PubMed:18653801).

EXTERNAL LINKS

fhuA

Ferrichrome outer membrane transporter/phage receptor

fhuA

Molecular Synopsis