FEATURES

DESCRIPTION

Also known as TRBM_HUMAN, THBD, THRM. Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated. Interacts with ITGAL, ITGAM and ITGB2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

THBD

Mutations

Mutation(s) distribution

Mutations table