FEATURES

DESCRIPTION

Also known as ASGR1_HUMAN, ASGR1, CLEC4H1. Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. Interacts with LASS2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ASGR1

Asialoglycoprotein receptor 1

ASGR1

Molecular Synopsis