FEATURES

FAMILY

Orn/Lys/Arg decarboxylase class-II family

DESCRIPTION

Also known as DCOR_TRYBB, DCOR. Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.

EXTERNAL LINKS

uniprot
enzyme classification

DCOR

Mutations

Mutation(s) distribution

Mutations table