FEATURES

FAMILY

DESCRIPTION

Also known as MOD5_YEAST, MOD5. Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in the anticodon loop on a specific subset of tRNAs both in the cytosol and the mitochondrion, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). This modification optimizes the codon:anticodon fit in the ribosome and promotes translational fidelity. Competes with the farnesyl pyrophosphate synthase ERG20 for the common substrate dimethylallyl diphosphate (DMAPP).

EXTERNAL LINKS

uniprot
enzyme classification

MOD5

tRNA dimethylallyltransferase

MOD5

Molecular Synopsis