FEATURES

FAMILY

DESCRIPTION

Also known as SIGM3_REOVL, S4. Stimulates translation by blocking the activation of the dsRNA-dependent protein kinase EIF2AK2/PKR, thereby inhibiting the host interferon response. Sigma3 prevents the activation of EIF2AK2 by competing with the kinase for dsRNA-binding (By similarity)., The viral outer shell polypeptides, of which sigma-3 is one, impose structural constraints that prevent elongation of nascent transcripts by the RNA-dependent RNA polymerase lambda-3. Heterohexamer of three sigma-3 and three Mu-1 proteins. The RNA-binding form is probably a homodimer (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

S4

Mutations

Mutation(s) distribution

Mutations table