FEATURES

FAMILY

DESCRIPTION

Also known as ACM2_HUMAN, CHRM2. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol. Interacts with ARRB1 and ARRB2. Interacts with RACK1; the interaction regulates CHRM2 internalization.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CHRM2

Mutations

Mutation(s) distribution

Mutations table