FEATURES

FAMILY

DESCRIPTION

Also known as ELNE_HUMAN, ELANE, ELA2. Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). Interacts with NOTCH2NL.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ELANE

Neutrophil elastase

ELANE

Molecular Synopsis