FEATURES

FAMILY

DESCRIPTION

Also known as GSTA1_HUMAN, GSTA1. Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3, 17-dione (AD) into D4-androstene-3, 17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z, 11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487). Homodimer or heterodimer of GSTA1 and GSTA2.

EXTERNAL LINKS

GSTA1

Mutations

Mutation(s) distribution

Mutations table