FEATURES

FAMILY

DESCRIPTION

Also known as RSSA_HUMAN, RPSA, LAMBR, LAMR1. Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA., (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2, 3, 8 and 9., (Microbial infection) Acts as a receptor for the Dengue virus., (Microbial infection) Acts as a receptor for the Sindbis virus., (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus., (Microbial infection) Acts as a receptor for the pathogenic prion protein., (Microbial infection) Acts as a receptor for bacteria. Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK (By similarity). The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.

EXTERNAL LINKS

RPSA

Mutations

Mutation(s) distribution

Mutations table